Postdoctoral Scholar, ADC Discovery Chemistry

At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity. Learn more at jnj.com.

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Job Function:

Career Programs

Job Sub Function:

Post Doc – Drug Discovery & Pre-Clinical/Clinical Development

Job Category:

Career Program

All Job Posting Locations:

Spring House, Pennsylvania, United States of America

Job Description:

About Innovative Medicine

Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow.
 

Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way.
 

Learn more at https://www.jnj.com/innovative-medicine   
 

We are searching for the best talent for a Postdoctoral Scholar, ADC Discovery Chemistry to be located in Spring House, PA.
 

Purpose: The Postdoctoral Scholar, ADC Discovery Chemistry will conduct independent research focused on the discovery and optimization of next‑generation mechanisms for antibody–drug conjugates (ADCs). This role will integrate medicinal chemistry, synthetic chemistry, and bioconjugation to translate novel linker-payload constructs into biologically validated ADCs.
 

You will be responsible for:

• Design, synthesis, and bioconjugation of novel linker-payload constructs.
   
• Applying medicinal chemistry principles to define structure-activity relationships and progress linker-payloads through DMTA cycles.
   
• Organizing scientific findings into clear summaries and communicate them to the broader ADC Discovery team.
   
• Participating in required trainings, development activities, internal meetings, and scientific symposia.
   

Qualifications/Requirements

Education:

• A PhD in Organic Chemistry, Medicinal Chemistry, Chemical Biology, or a related field is required.
   

Experience and Skills:

Required:

• Extensive experience and record of accomplishments in organic and/or medicinal chemistry, including evidence of complex, multistep syntheses.
   
• Ability to design experiments independently, interpret complex datasets, and draw scientifically sound conclusions.
   
• Strong project management skills and the ability to independently prioritize tasks in a complex, fast-paced, dynamic environment.
   
• Effective collaboration skills and comfort working in cross-functional, multidisciplinary research teams.
   
• Exceptional written and verbal communication skills, including the ability to present scientific findings clearly to diverse audiences.
   

Preferred:

• Prior research experience in ADCs, linker-payload chemistry, or targeted drug delivery.
   
• Experience with bioconjugation chemistry and ADC characterization (e.g., DAR analysis, SEC, HIC).
   
• Strong understanding of drug-like physicochemical properties and their effect on biological performance.
   

Johnson & Johnson is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, disability, protected veteran status or other characteristics protected by federal, state or local law. We actively seek qualified candidates who are protected veterans and individuals with disabilities as defined under VEVRAA and Section 503 of the Rehabilitation Act.
 

Johnson & Johnson is committed to providing an interview process that is inclusive of our applicants’ needs. If you are an individual with a disability and would like to request an accommodation, external applicants please contact us via https://www.jnj.com/contact-us/careers, internal employees contact AskGS to be directed to your accommodation resource.
 

If you are under 18 years of age, you (the candidate) may need to obtain the necessary working papers or other documentation required by state law to start the assignment, as well as get a parent’s consent for the background check.
 

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Required Skills:

 

 

Preferred Skills: