AI Security Operations Engineer 

The AI Security Operations Engineer is responsible for securing, operationalizing, and scaling AI, Generative AI, and Agentic AI systems across the enterprise. This role bridges security architecture, AI governance, and operational security, ensuring AI systems are designed, deployed, and monitored with security‑by‑design and runtime assurance. 

This role operates as a hands‑on technical leader and trusted advisor to engineering, AI, and business stakeholders, translating AI risk into actionable security controls without slowing innovation. 

Key Responsibilities 

• Lead security design and operational oversight for AI, Generative AI, and Agentic AI initiatives across the enterprise  

• Define and operationalize AI security frameworks, standards, and review processes that govern model lifecycle, data usage, and autonomous behavior 

• Conduct AI‑focused security architecture reviews and threat modeling to identify and mitigate risks before deployment 

• Support and monitor agentic and autonomous AI workflows, ensuring guardrails, accountability, and runtime visibility 

• Partner with AI leadership and accelerator programs to enable secure AI adoption at scale 

• Translate complex AI and cybersecurity risks into clear business and patient‑impact narratives for senior leadership 

• Contribute to and evolve enterprise AI governance programs, aligning with global regulatory expectations (e.g., NIST AI RMF, EU AI Act, privacy frameworks) 

• Enable continuous improvement of AI security operations through automation, metrics, and repeatable processes 

Required Qualifications 

• Bachelor's Degree

• 7+ years of experience in cybersecurity architecture, security engineering, or security operations 

• Demonstrated expertise securing cloud, hybrid, and on‑prem environments (AWS, Azure, GCP)   

• Hands‑on experience with AI/ML security, Generative AI, and Agentic AI concepts 

• Proven ability to build and scale enterprise security frameworks for emerging technologies 

• Strong background in threat modeling, risk analysis, and secure solution design 

• Experience advising and influencing multiple stakeholders across hundreds of initiatives annually 

• Ability to operate independently while shaping strategy and execution 

Preferred / Differentiating Skills 

• Experience designing or contributing to enterprise AI cybersecurity frameworks 

• Background supporting AI governance and accelerator programs 

• Knowledge of global regulatory and compliance requirements (NIST AI RMF, EU AI Act, GDPR, HIPAA, PCI‑DSS)   

• Experience in life sciences, healthcare, or highly regulated environments 

• Certifications in AI governance or cybersecurity (e.g., AIGP, CISSP, CISM, CISA) 

What Success Looks Like 

• AI initiatives move faster because security is embedded early, not reviewed late 

• Agentic AI systems are deployed with clear guardrails, monitoring, and accountability 

• Security reviews scale across hundreds of AI and non‑AI projects annually without becoming a bottleneck 

• Leadership has clear visibility into AI risk, posture, and readiness 

When we put unexpected teams in the same room, we unleash bold thinking with the power to encourage life-changing medicines. In-person working gives us the platform we need to connect, work at pace and challenge perceptions. That's why we work, on average, a minimum of three days per week from the office. But that doesn't mean we're not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world.

The annual base pay for this position ranges from $136,044.00 - $204,066.00 USD Annual. Hourly and salaried non-exempt employees will also be paid overtime pay when working qualifying overtime hours. Base pay offered may vary depending on multiple individualized factors, including market location, job-related knowledge, skills, and experience. In addition, our positions offer a short-term incentive bonus opportunity; eligibility to participate in our equity-based long-term incentive program (salaried roles), to receive a retirement contribution (hourly roles), and commission payment eligibility (sales roles). Benefits offered included a qualified retirement program [401(k) plan]; paid vacation and holidays; paid leaves; and, health benefits including medical, prescription drug, dental, and vision coverage in accordance with the terms and conditions of the applicable plans. Additional details of participation in these benefit plans will be provided if an employee receives an offer of employment. If hired, employee will be in an “at-will position” and the Company reserves the right to modify base pay (as well as any other discretionary payment or compensation program) at any time, including for reasons related to individual performance, Company or individual department/team performance, and market factors.

Are you ready to bring new insights and fresh thinking to the table? Fantastic! We have one seat available, and we hope it’s yours. Apply today.

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We follow all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.