Global Commercial Director, ImmunoOncology

Location: Wilmington
Hybrid Policy: 3 days a week onsite

As Global Commercial Director, ImmunoOncology, this role shapes how ground-breaking oncology medicines reach patients worldwide. Working across a broad and innovative pipeline, the position blends commercial competence with scientific understanding to bring novel treatments to those who need them most. It leads the commercial strategy for key immuno-oncology disease areas, with a particular focus on the end-to-end launch and sustained performance of the MATTERHORN gastric cancer programme. Operating at the centre of cross-functional collaboration, this role drives focused execution, informed decision-making and ambitious, insight-led choices that influence outcomes for patients, markets and the business. Ready to challenge convention, test new ideas and guide a high-performing team to deliver impact at scale?

Accountabilities

• Lead the creation, execution and continuous refinement of a long-term commercial vision and strategy for immuno-oncology disease area(s), ensuring robust lifecycle management from prelaunch through postlaunch.

• Chair and direct the IO disease area(s) Global Brand Team (GBT), setting clear priorities, driving accountability and ensuring coordinated delivery across functions and phases of launch.

• Hold global budget accountability for the disease area, including development of the annual operating plan, budget phasing, investment prioritisation

• Own global commercial leadership of the MATTERHORN gastric cancer launch, ensuring launch excellence, sustained performance and delivery against strategic and financial objectives.

• Lead all aspects of postlaunch performance by monitoring uptake, driven dynamics, access and executional efficiency, initiating data-driven course corrections and reallocating resources where needed.

• Represent and articulate the commercial and marketing strategic vision for the disease area(s) within the Global Portfolio Team (GPT), influencing key decisions and trade-offs.

• Partner closely with the Global Medicines Lead (GML) to align commercial and medical strategies, ensuring integrated planning and coordinated resource deployment.

• Develop and implement commercial strategies that optimise revenue, volume, margin and access across geographies within agreed budget envelopes.

• Engage regional and key market stakeholders to drive launch readiness, build capabilities and ensure effective deployment of global and local budgets.

• Act as indication lead in senior forums, communicating commercial performance, financial outlooks and investment trade-offs to senior executives and governance committees.

• Deliver Phase 3 and prelaunch marketing strategies that set up successful launches and maintain strong postlaunch momentum.

• Collaborate with extended teams to develop and implement sustainable pricing and access strategies across multiple indications.

• Lead the development and global implementation of brand strategy, positioning, launch plans, forecasts, critical metrics and ongoing financial and performance analytics for the disease area(s).

Essential Skills/Experience

• Strong strategic thinking, judgment, and influencing skills to lead across regions and markets with clear financial accountability. 

• Demonstrated experience owning or leading significant global commercial budgets, including investment prioritization, phasing, and governance. 

• Confirmed ability to use performance and financial analytics to inform decision making and drive course corrections. 

• Bachelor’s degree required; preferably a business or scientific graduate degree with a business related postgraduate qualification. Postgraduate degree in biological, chemical, or pharmacological sciences strongly desired. 

• 10+ years’ experience in the pharmaceutical industry, including at least 5 years in oncology/immuno-oncology marketing, strategy, or life sciences consulting. 

• Strong leadership capabilities to set direction, inspire commitment, balance short and longterm financial and strategic needs, and resolve complex issues. 

• Strong business acumen and complex problem solving skills. 

• Experience developing and delivering short and longterm strategic plans for oncology portfolios, including postlaunch performance and budget management. 

The annual base pay for this position ranges from $231,988.80 - $347,983.20 USD Annual and salaried non-exempt employees will also be paid overtime pay when working qualifying overtime hours. Base pay offered may vary depending on multiple individualized factors, including market location, job-related knowledge, skills, and experience. In addition, our positions offer a short-term incentive bonus opportunity; eligibility to participate in our equity-based long-term incentive program. Benefits offered included a qualified retirement program [401(k) plan]; paid vacation and holidays; paid leaves; and, health benefits including medical, prescription drug, dental, and vision coverage in accordance with the terms and conditions of the applicable plans. Additional details of participation in these benefit plans will be provided if an employee receives an offer of employment. If hired, employee will be in an “at-will position” and the Company reserves the right to modify base pay (as well as any other discretionary payment or compensation program) at any time, including for reasons related to individual performance, Company or individual department/team performance, and market factors.

At AstraZeneca, we pride ourselves on crafting a collaborative culture that champions knowledge-sharing, ambitious thinking and innovation – ultimately providing employees with the opportunity to work across teams, functions and even the globe. 

When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working gives us the platform we need to connect, work at pace and challenge perceptions. That’s why we work, on average, a minimum of three days per week from the office. But that doesn't mean we’re not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world.

Apply now!

Date Posted

19-May-2026

Closing Date

07-Jun-2026

Our mission is to build an inclusive environment where equal employment opportunities are available to all applicants and employees. In furtherance of that mission, we welcome and consider applications from all qualified candidates, regardless of their protected characteristics. If you have a disability or special need that requires accommodation, please complete the corresponding section in the application form.