Associate Principal Scientist, Immunology Cell Therapy Discovery

AstraZeneca, a global leader in biopharmaceuticals, is committed to discovering and delivering innovative therapies that transform patient outcomes. We are seeking a dedicated, hands-on Associate Principal Scientist or Principal Scientist to join our Immunology Cell Therapy Discovery team. This role will provide scientific and technical leadership across discovery initiatives with a dual emphasis on immune mediated diseases and computational innovation, with particular focus on bioinformatics, data science, and AI architecture to accelerate cell therapy discovery.

The successful candidate will operate at the interface of immunology, computational biology, and AI-enabled research, partnering across multidisciplinary teams to advance target identification, patient stratification, translational insights, and platform capabilities that support AstraZeneca’s discovery portfolio.

Key Areas of Focus

1. Bioinformatics

Lead and apply advanced bioinformatics approaches to support research in immune mediated diseases. This includes the design and implementation of robust analytical workflows for bulk and single-cell RNA sequencing, immune repertoire analysis, multi-omics integration, target and pathway identification, and biomarker or endotype discovery. The role requires strong emphasis on reproducibility, data quality, statistical rigor, and the generation of actionable biological insights that inform experimental strategy and portfolio decisions.

2. Data Science

Drive data science strategies that integrate complex biological datasets to improve understanding of disease heterogeneity, preclinical readout, and mechanism of action. The role will involve developing and applying statistical models, machine learning approaches, and advanced data integration methods to support hypothesis generation, patient segmentation, and evidence-based decision-making. The individual will also contribute to building scalable and interpretable analytical frameworks that connect computational findings with experimental validation.

3. AI Architect

Serve as an AI Architect within the discovery organization, acting as an expert in AI-enabled coding who can design, develop, and maintain reusable codebases that improve productivity, scalability, and scientific innovation. The role will lead innovation by integrating AI into core workflows, contribute to or build AI-powered applications, and help drive transformation by advancing AI-driven discovery. This includes architecting practical AI solutions for scientific workflows, enabling automation, improving knowledge extraction, and establishing sustainable coding and software practices that enhance research efficiency and impact.

Accountabilities

• Bioinformatics and Computational Discovery: Design, implement, and continuously improve analytical workflows for bulk and single-cell transcriptomics, immune repertoire analyses, multi-omics integration, and biomarker/endotype discovery, ensuring reproducibility, quality control, and scientific rigor.

• Data Science Innovation: Apply advanced data science and machine learning methods to derive insights from high-dimensional biological and translational datasets, supporting target selection, patient stratification, mechanism-of-action studies, and portfolio prioritization.

• AI Architecture and Enablement: Design, develop, and maintain reusable AI-enabled codebases and computational frameworks; integrate AI into core discovery workflows; contribute to or build AI-powered applications; and advance the use of AI to improve scientific decision-making and discovery efficiency.

• Stakeholder Engagement: Build strong partnerships with key stakeholders internally and externally to align scientific, computational, and AI strategies with broader R&D priorities; communicate complex findings clearly to both technical and non-technical audiences.

• Governance and Compliance: Ensure compliance with relevant laws, regulations, and company policies related to the development and delivery of medicines, including expectations for data governance, privacy, and responsible use of human-derived datasets.

Essential Skills and Experience

• Education and Industry Experience: PhD with 5+ years of relevant biotech or biopharma industry experience in Immunology, Computational Biology, Bioinformatics, Molecular Biology, Cell Biology, Bioengineering, Data Science, or a related discipline.

• Bioinformatics Expertise: Demonstrated expertise in bulk RNA-seq, single-cell RNA-seq, immune repertoire analytics, integrative multi-omics, and biomarker/endotype discovery, with a strong understanding of analytical design, quality control, and interpretation in a discovery setting.

• Data Science Expertise: Strong experience in statistical modeling, machine learning, data integration, and data visualization, with the ability to extract meaningful and decision-relevant insights from complex biological and translational datasets.

• AI Architecture and Software Development: Proven ability as an AI-enabled coder to design, develop, and maintain reusable codebases, contribute to or build AI-powered applications, and integrate AI solutions into scientific workflows to improve efficiency and innovation.

• Programming Skills: Strong programming proficiency in Python and/or R, with experience in workflow reproducibility, version control, modular code development, and scalable analytical pipelines.

Desirable Skills and Experience

• Industry Network: Established connections within immunology, computational biology, data science, or AI communities, including experience collaborating with CROs, academic groups, or research consortia.

• Publication Record: Strong track record of peer-reviewed publications in immunology, computational biology, bioinformatics, data science, or related fields.

• Therapeutic Modality Breadth: Experience working across multiple therapeutic modalities, including cell therapies, biologics, and/or small molecules, and familiarity with combination strategies relevant to autoimmune and allergic indications.

• AI Application Development: Experience building internal scientific tools, decision-support systems, workflow automation tools, or other AI-powered applications that enhance research productivity and discovery quality.

At AstraZeneca, we push the boundaries of science to change the practice of medicine and transform the lives of patients living with cancer. With one of the broadest and deepest Immunology pipelines in the industry, there are many opportunities to work with new and novel drugs. Our collaborative environment empowers us to take smart risks, challenge the norm, and learn from failures. We are united in our vision to eliminate cancer as a cause of death, making bold moves that truly improve patient outcomes. 

Join us in our mission to make a meaningful difference for patients around the world!